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Endocrine influence
AJP - DHA helps to reduce cellular impairment in insulin-resistant and insulin-deficient induced rat, findings reported
ANS – N-3 fatty acids incorporate into red blood cells
ASO - n-3 inhibits increase of cancer cells in pancreas
CDS - Ω-3 may benefit Cystic Fibrosis
Circ - Fish eaters found to have lower leptin levels, compared to vegetarians
EBM – Omega-6/3 Ratio in Cardiovascular and Chronic Diseases
Endocrine - Low intake of Ω-3 alters pancreatic function.
KI – Vitamin D may benefit the kidneys and cardiovascular system.
NEJM - Associations between decreased insulin sensitivity and fatty acid levels in skeletal muscle
Glucose maintenance
AJCN - EPA and DHA and people with type-2 diabetes and high blood pressure, no impact on glycated hemoglobin
AJCN – Association between n-3s and plasma.
AJCN – Ω3 shown to reduce adiposity in women with type 2 diabetes
BJN - DHA an indicator of cardiovascular health status
BJN – EPA has beneficial effects on insulin resistance in rats.
BP – Fish oil modulates blood pressure
CardioD – Long chain PUFAs may be useful in combating diabetes and metabolic syndrome
DIAB - Omega-3 fats protect from high-fat diet-induced insulin resistance, mechanism proposed.
Endocrine – Low omega glucose metabolism insuline release in rats.
FASEB - Omega-3 may prevent obesity-related complications
JCEM – Vitamin D and Calcium may prevent type 2 Diabetes
PLEFA - How omega-3s help the heart, brain, and gut - plausible explanation
Lipids and triglycerides
AHRQ - Fish and fish oil consumption reduce all-cause mortality and various CVD outcomes
AJCardio - DHA improves lipid measures in hyperlipidemic children
AJCN - EPA and DHA on a daily basis enriches blood lipids
AJCN - Essential fatty acids in health and chronic diseases
AJCN - Fish oil reduces heart disease risk in menopausal women - HRT or not
AJCN - Fish oil with GLA improved lipid and fatty acid profiles in women, measurably reducing heart attack risk
AJCN - Increasing EPA and DHA improved blood lipids and did not affect blood clotting factors
AJCN - omega 3s have beneficial effects on adipose tissue
AJCN - Omega-3s and dietary counseling improve endothelial markers in hyperlipidemic men
AJCN - Prevention And Treatment Of CHD With Omega-3 FAs
AJCN – Alcohol boosts omega-3 in blood
AJCN – DHA Improves Lipid Profiles
AJCN – fish, fish oil, smoking cessation, and exercise for prevention of CHD
ANYAS - Dietary fats and hypertension
APJCN – Omega-6/3 Ratio, Genetic Variation and Cardiovascular Disease
AR – Omega 3s can lower triglyceride levels in AIDS patients.
ASN - n-3 fish oil has anticoagulant effect in overweight subjects.
ASN – Fish oil associated with improvement in systemic lipid homeostasis and atherosclerosis in mice.
Ath - Review of omega-3 from plant and fish oil and heart health markers
ATVB – Omega-3 Rich Diets Decrease Arterial Total LDL Delivery
BJDVD - Omega-3 FAs, CVD, Hypertriglyceridaemia and Diabetes Mellitus
BJN - DHA effects serum lipids thus promotes cardio health
BJN – Increased n-3 consumption is associated with reduced cardiovascular risk.
BJN – Omega-3 FAs and exercise reducing inflammation
Circ - Dietary Fish Reduces Risk Of Cardiac Death
CMJ - Benefits of Omega-3’s and Red Yeast Rice on Cardiovascular Health
Curr Opin Lipidol – Changes in dietary fat helps regulate lipid metabolism
EJCN – Fish oil improves hemodynamic parameters in subjects with type II diabetes
EJCN – Omega-3s may amend lipids in diabetes patients
EOP – n-3 FA effective in reducing triglycerides
EurJAP - Fish oil supports healthy brachial blood flow during exercise
FASEB - Inflammation reduced by fish oils
GP - Fish oil improves lipid profiles in women taking or not taking oral contraceptives
Heart - Fish oil and statin meds in CHD
HM – Fish oil lowers blood lipids in HIV positive patients.
JN - DHA may lessen the inflammatory response
JN – DHA decreases cholesterol in men with high triglyceride levels
JN – Omega-3 PUFAs shown to regulate blood pressure in patients on hemodialysis
JNB – Omega-3 Diet Reduces Hypertension.
JNut - Exercise and nutrition supplements, e.g. fish oil, recommended as first line of defense for lowering cholesterol
JS – omega-3 reduces cell reactivity
Lancet - Fish Oil, Omega-3 Fatty Acids help Cardiovascular Disease
Lancet - Omega 3 reduces mortality in heart failure
Lipids – Fish Oil may help treat hyperlipidæmia.
MCP - Omega-3 Fatty Acids For Cardioprotection
MCP – Lifestyle changes, red yeast rice, fish oil reduced LDL-C similar to statins.
Metabolism – Omega-3 has comparable effects on lipid parameters as fenofibrate
NEJM - inverse relation between fish consumption and CHD mortality
NH - Scientists suggest that diet is the source of fats circulating in the body
NRR – ALA not the best source of DHA and EPA
Nutrition – FO enriched milk improved CV risk factors
PLEFA - Animal study suggests association between DHA and lipoproteins, especially in brain, heart, and brown fat
PLEFA - Fatty acids have an important role in lipid structure and membrane trafficking
PLEFA - Study shows beneficial effects of fish oil prior to cardiac surgery
PLEFA – Omega-3 Gene And Protein Expression Profiling
PLOS – Preventable Causes of US Deaths
PNAS – DHA alters bilayer elastic properties
Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids
Metabolic parameters
AER – Omega 3 reduces pain and hypertension
AJCN - EPA and DHA and people with type-2 diabetes and high blood pressure, no impact on glycated hemoglobin
AJCN - Omega-3 fats from fish associated with lower levels of C-reactive protein levels
AJCN - Recommends global consideration of fish oil for metabolic syndrome
AJCN - Study reports beneficial impact of fish oils on heart rate
AJCN – Low omega-3 intake will not effect adiposity in overweight men or women
AJCN – Omega-3 fatty acids and exercise reduce body fat and improve cardiovascular and metabolic health.
ATVB - n-3 and n-6 ratio must be considered when reducing saturated fat intake
BJN – Omega-3 FAs and exercise reducing inflammation
CardioD – Long chain PUFAs may be useful in combating diabetes and metabolic syndrome
Circ - Fish oil shown to regulate heart beat in patients and rabbits.
Circ - Meta-analysis report, fish oil reduces heart rate in those with higher heart rates, best results when fish oil is consumed for more than 12 weeks
EJCN – Fish oil improves hemodynamic parameters in subjects with type II diabetes
JACC - Large study, those who eat fish have reduced inflammatory markers, less risk for heart disease
JAMA – Omega-3 not effective for prevention of relapse in Chrohns disease
JBC – Increasing EPA will favorably effect heart and inflammatory system
JC – EPA shown to reduce blood pressure without altering heart rate in men
JHH – Fish oils aid in metabolic properties in hypertensive males
JNut - Omega-3 fats associated with lower levels of inflammatory markers, from Nurses Health study
JNut - omega-3s fatty acids associated with lower inflammatory markers, helps explain how they help reduce heart disease risk
JRheum - 3 year investigation, multiple benefits from fish oil for heart and rheumatoid arthritis
Lancet - Fish Oil, Omega-3 Fatty Acids help Cardiovascular Disease
Lancet - Omega 3 reduces mortality in heart failure
Metabolism – Fish Oil enhances growth
Metabolism – Omega-3 has comparable effects on lipid parameters as fenofibrate
MH – High intake of fish oil may be of therapeutic benefit in congestive heart failure
Primary prevention
ACCardio - Omega-3s from fish, and diets rich in baked or broiled fish, are associated with reduce risk for heart failure
AFP - Omega-3 fatty acids as Benefiting CHD
AHRQ - Fish and fish oil consumption reduce all-cause mortality and various CVD outcomes
AIM - Fish Oils and Atherosclerosis
AIM - Results from a large, systematic review report that fish oil improves mortality, even compared to statins.
AJ Cardio - Relationship between DHA and CRP reported
AJC – Fish oil supplementation increases heart health
AJC – Low levels of EPA and DHA may be a risk factor for Acute Coronary Syndrome.
AJCN – EPA has strong association with physical well-being
AJCN – Fish consumption associated with protection from cardiovascular disease.
AJE - EPA and DHA may provide different levels of protection for colorectal cancer.
AJEpi - Eating fish and omega-3 from fish reduces risk for MI
AJM - Fish oil improves tolerance of cold in patients with Raynaud's disease.
AJPHCP - Reducing O6 and increasing O3 greatly reduces cardiovascular risk
AJPM - Omega-3s estimated to be more effective in preventing sudden death than automated external defibrillators (AEDs)
Athersclerosis - DHA shown to reduce coronary heart disease
Athersclerosis – EPA improves carotid IMT baPWV
ATV - Proper Ω-3/Ω-6 ratios are necessary when reducing saturated fat intake.
ATVB - Mercury attenuates the benefits of fish oils, best avoided
ATVB – American Heart Association 2003 Recommendations
BiomedP - The Importance of the Ratio of Omega-6/Omega-3 Essential Fatty A
BJDVD - Omega-3 FAs, CVD, Hypertriglyceridaemia and Diabetes Mellitus
BJMBR – LCFAs and inflammation: application in surgical and trauma patients
BJN - the combination of exercise and fish oil supplementation, may help counteract inflammation
CEBP - Fish oil not shown to enhance cancer cells in rats.
Chest - Fish oil shown to help heart rate variability among seniors
Circ - New 2006 Diet and Lifestyle recommendations from the Heart Association
Circ - Consuming Fish and Omega-3 Fatty Acids from fish reduce risk of heart disease in women with diabetes
Circ - Fatty Acid Level as a Predictive Risk Factor for Sudden Death
Circ - Oily fish help prevent sudden cardiac death
Circ - Reduction in heart rate with fish oils, consistent finding
CMAJ - Use of Fish Oil in ICD Patients Warrants Caution
COL – Omega 6:3 Ratios Relevant To Diet And Maintaining Proper Health
CS - Fish oil improves heart function in healthy men
DOM - Ω-3 status is influenced by inflammatory status.
EHJ - Caution when prescribing fish-oil supplementation for patients with defibrillators (ICD)
EJCN - Correlations between DHA and folate in men
EJCPR - Omega-3 PUFA supplementation imposed a favorable effect on arterial elasticity.
EurJAP - Fish oil supports healthy brachial blood flow during exercise
FASEB – EPA and DHA associated with less aortic lesion formation.
Heart - Systematic review: authors conclude that ALA, as found in flax seed oil, does not improve heart risk factors
JA – Vitamin D Deficiency and Cardiovascular Disease
JACC – Dietary PUFA supplementation may improve heart function in patients with stable congestive heart failure.
JAMA - Benefit vs. risk: Omega-3s significantly reduce coronary death and mortality
JAMA - Fish Intake Lowers Risk of Stroke in Men
JAMA – Omega-3 not effective for prevention of relapse in Chrohns disease
JCM - EPA and DHA can provide therapy for sudden cardiac death
JHH - Increase the ratio of omega-3:omega-6
JLR - More DHA associated with less coronary atherosclerosis in women
JLR - Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes.
Lancet - Omega 3 reduces mortality in heart failure
Lipids - Body size and presence of diabetes, but not gender, may influence one's blood level of omega-3
MH – High intake of fish oil may be of therapeutic benefit in congestive heart failure
NCPCM - EPA supplementation in high Ω-3 diets shown to reduce adverse cardiac events.
NMCD – Omega-3 enriched diet improves cardioprotection but cannot reverse effects of forced exercise.
NR – Supplementing with stable fish oil results in high efficacy
OH – Protective benefits of omega-3 fatty acids are legitimate in primary and secondary prevention
PC - Omega 3s may help cut risk of coronary heart disease
PLOS – Preventable Causes of US Deaths
PsyR - Low DHA levels associated with cardiovascular health and depression
Secondary prevention
AFP - Omega-3 fatty acids as Benefiting CHD
AHRQ - Fish and fish oil consumption reduce all-cause mortality and various CVD outcomes
AJC - More on how fish oil helps reduce risk for sudden cardiac death
AJCN - EPA and DHA help improve cardiac health.
AJCN - Prevention And Treatment Of CHD With Omega-3 FAs
AJCN – fish, fish oil, smoking cessation, and exercise for prevention of CHD
AJE - EPA and DHA may provide different levels of protection for colorectal cancer.
ANYAS - Dietary fats and hypertension
AS - Using fish oil after abdominal surgery may reduce infections
BJDVD - Omega-3 FAs, CVD, Hypertriglyceridaemia and Diabetes Mellitus
BJMBR – LCFAs and inflammation: application in surgical and trauma patients
BJP - Omega 3 treatment prevents acute atrial electrophysical remodeling.
Circ - Fish oils appears to reduce potentially fatal ventricular arrhythmias (VAs) in patients with ICDs
Circ - Broiled or Baked Fish Associated With Lower Heart Disease Risk
Circ - Fatty Acid Level as a Predictive Risk Factor for Sudden Death
Circ - Fish oil shown to regulate heart beat in patients and rabbits.
CMAJ - Use of Fish Oil in ICD Patients Warrants Caution
CR - Omega 3s alleviate heart dysfunction in rats.
EJCN - Fish Oil improves artery elasticity.
GISSI trial - Cost-effectiveness of omega-3 fatty acids after MI
JAMA - Study reports fish oil does not reduce time to VT or VF in patients with ICDs.
JLR - DHA and EPA help inhibit lymphocyte proliferation.
JNB – Omega-3 Diet Reduces Hypertension.
LV - Ω3 shown to be a significant secondary prevention in heart patients
NCPCM - EPA supplementation in high Ω-3 diets shown to reduce adverse cardiac events.
NEJM - Blood Levels of Long-Chain n-3 Fatty Acids and the Risk of Sudden Death
Nephrology - Fish Oil slows development of athersclerosis in dialysis patients.
NHA - Evidence review of fish oils in sudden cardiac health
OH – Protective benefits of omega-3 fatty acids are legitimate in primary and secondary prevention
PLOS – Preventable Causes of US Deaths
ZWCWKZZ - omega-3PUFAs inhibit the growth of gastric cancer cells through promoting apoptosis
 

 


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