The use of omega-3 fatty acids for depression treatment is of considerable interest, in part due to the inadequate efficacy and tolerability of standard antidepressant medications. Although several meta-analyses have reported positive outcomes for omega-3 fatty acid treatment of depression, an up-to-date meta-analysis by Bloch and Hannestad that includes the latest trials and uses sophisticated meta-regression techniques to account for study heterogeneity, suggests no significant benefit.

PMID: 22824812

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